[3 Types of Inflammation] Lupus, Autoimmune SLE Rheumatologist Doctor Explains Chemical Pathways

Have Lupus? Want to stop INFLAMMATION for good?

“Fuel the Mind, Heal the Gut, Reclaim Immunity”

Have Lupus? Want to stop INFLAMMATION for good?


There are many forms of inflammation that can make lupus symptoms worse. Here are 3 to look out for:

Biochemical Pathways of Inflammation (There are more than just three)

   ​1) Histamine Pathway

        ​a. Histamine is produced in the gut mostly ('bad' microbes)

        b. HistaDINE is the precursor molecule

        c. Dietary sugar stimulates 'bad' microbes (Yeast, Candida, Bacteria)

   ​2)   Arachidonic Acid Pathway

        ​a. From animal-derived cholesterol

   ​2)   TNF-a, IL-6 (Tumor Necrosis Factor Alpha and Interleukin-6)

        ​a. Produces a dysfunctional immune response

        b. Vitamin D deficiency causes elevations in TNF-a/IL-6

        c. Phytonutrients help block TNF-a/IL-6





There are a whole host of conditions associated with dysfunctional immune inflammation, the list includes: Eczema, Allergies, UTIs, Irritable Bowel (IBS), IBD, Crohn's/Colitis, SIBO, Candida, GERD, Viral illnesses, Autism, Multiple Sclerosis, Lupus, Rheumatoid Arthritis, Mixed Connective Tissue Disorder, Sjrogrens, Autoimmune Thyroiditis, Migraine Headache, Neuropathy, and Fibromyalgia


Although I am a licensed, and practicing surgeon, with over a decade of experience helping people overcome inflammatory disease,  the presented material is intended for educational purposes only and should not be construed as medical advice. Please use your best judgment and consult with a healthcare professional regarding your needs.


"As always: Be TRUE to yourself. Surround yourself with people who affirm your wellbeing. Find a doctor who will slow down to listen. Find one who carefully considers your concerns and most of all--find one who cares."

Dr. Chanu R. Dasari MD

You hear the word inflammation thrown around a lot. Well, what

is it exactly and how does it actually happen?

Hi everyone. I'm Dr. Chanudasri. I help my

clients solve their immune inflammation and digestive dysfunction using

the Mind get immunity method.

This clinical approach has helped thousands of my patients resolve

their symptoms summon as little as six weeks without the

need for complex or costly interventions in this

video. I'll show you the three major Pathways of inflammation that

make lupus symptoms worse. I'll show

you how the inflammation works on a biochemical level and

how to avoid these damaging Pathways to reverse

inflammation fast. This topic gets a little

bit into the weeds. But I promise if you stick around till

the end, I'll review some practical points that you can use

to help avoid inflammation and resolve symptoms this

material you're about to watch is taking straight out of my mind getting immunity

or people just like you learn how to

beat their lupus symptoms for good. Even when the

diagnosis is unclear in the course. We review several

additional Pathways that can be useful for addressing inflammation

in some of my other videos. I mentioned that there are

five main triggers for Lupus inflammation and these five

triggers include diet digestion sleep stress

and exercise and if you want to


That video for some background take a look at the link up here. Now

before we go any further. Don't forget to like And subscribe

and hit the notification Bell to keep up to date. I make

must see videos for anyone with lupus looking

to reverse their symptoms for good.

And it's really helpful information that you probably won't get anywhere

else now on the topic of inflammation the mistake

I see most people make is that they think inflammation is

just one process, but in actuality, there's

hundreds of biochemical Pathways involved and if

your symptoms are really bad, you can have several of these Pathways

involve simultaneously knowing what

activates inflammation and how it works can help

you overcome and prevent it from happening in the first place.

That's why it's really important to be at least aware of

some of the key types of inflammation.

Now recall what I said in my other video that most inflammations

starts in your gut now you shouldn't

be surprised by this considering around 70 to 80

percent of your immune system is contained in your gut.

So when you have an inflammatory disease such as

lupus you need to take a look at what's going

on with diet and digestion frequently inflammation

starts in the intestine. So to heal inflammation, you

also need to heal the gut. So before we discuss the

three types of inflammation, if you are serious about

healing the gut to improve lupus and Achieve

results fast, check out a free training that I put

together where I walk you through the specific strategies that have helped my

clients achieve success within six weeks. You can

access it at the link down below and I know

it'll help you very much the link takes you to a page where you can enter

in your email to receive a free training on how to reverse lupus

everything you need to know is in there including free guide

with specific dietary recommendations and tons

of helpful case studies that people just like you who reverse


Additions for good and are now healthy the cases are

valuable because you'll see how real people deal with inflammation and how

they were able to improve their condition just by making a few small changes.

The training comes with a complete actionable game

plan for how you can do this yourself at home. So just

enter in your email at the top of the page and get started.

Now let's talk about the three types of inflammation. I recorded

this video earlier and it discusses how they immune system

is activated in three ways. The histamine pathway

is probably one of the most important ones to know here's an

example of one of my patients who had high amounts

of eosinophils due to candida overgrowth in his gut

His histamine levels were so high that all he had to do

was gently stroke his skin and in 30 seconds,

it would turn bright beat red.

This is called dermatographia and it's actually a form of


Unfortunately many people have this type of histamine

reaction always and have no clue.

I just want to correct one misconception. Most people

think that if they have allergies that it's coming from something in

the environment like grass or hay or

flowers or dust or mold.

While this is partially true, it's important

to know that most of the histamine in the human body

is actually produced in the gut by intestinal

bacteria that convert histidine into


Histidine is an amino acid found in certain

types of protein. It gets converted into histamine, which

triggers allergic reactions in the


So it's an important to limit both histidine containing foods

and histamine stimulating Foods. They include

things like shellfish peanuts and

pineapples, but the biggest stimulator is actually simple

carbohydrates, like sugars breads crackers

chips juices pasta candies and

certain types of fruit.

It turns out all of these sugary Foods Feed bad

bacteria and stimulate overgrowth of candida.

Which is a type of yeast and fungus this bad bacteria and

candida produce super high amounts of

histamine in the bloodstream, which leads the things like

allergies tiredness indigestion rashes hives

body aches and runny nose. So how

do we use this knowledge to our advantage? Well one simple

answer is a eat fewer starchy Foods.

B eat more green leafy vegetables and

high fibers Foods

C improve your intestinal Flora with regular

bowel movements two to four times a day.

probiotics also two to four times a day and phytonutrients

D stay away from foods that are high in

histidine, which is a precursor molecule to

histamine now would be a good time to point out that most

people think that you need to take an antibiotic or an

antifungal to clear intestinal bacteria overgrowth in


The reality is all you really need to do is

have two to four bowel movements a day so that you

get rid of The Unwanted bugs in your

GI system. Then you can repopulate the system two

to four times a day with probiotics you do

this in antibiotics and antifungals are rarely needed.

Also if you happen to take an antibiotic

or antifungal just remember that it only works for the

first few days, then the GI track it's repopulated with bacteria

in Canada. Especially if the diet is bad to

summarize a histidine pathway. There are histidine amino

acids in the diet that get converted into histamine when

we eat certain foods that cause overgrowth of

bacteria and candida in the system.

This histamine that's released into bloodstream produces. Allergies

sinus drainage sore throat

itchy. Scaly dry skin, asthma shortness

of breath pain and fatigue. Okay,

we'll be moving on now.

Here is the arachidonic acid pathway.

All animal cells have a membrane wall that contains

fats and cholesterol which convert into

arachidonic acid and cytokines in

our bodies and generate inflammation. Do all

animal derived products contain arachidonic acid. No,

just me and fat containing

dairy products.

Remember the arachidonic acid doesn't come from

the protein component. It comes from the fat and the cholesterol in

the cell wall.

So for example egg whites are pure protein,

so they don't contain arachidonic acid.

Marine and Bovine collagen also do

not contain arachidonic acid.

Fat-free yogurt and bone broth are other examples.

But something like red meat has a lot of fat and cholesterol in

it. So rackodonic acid production is especially bad,

but unfortunately even white meat poultry and

fish contain substantial amounts because they

contain lipid cholesterol for this reason limiting

meat and dairy intake improves inflammation.

Now I want to talk about the salt pathway.

So here's the thing everyone knows that when they

eat large amounts of salt, they feel very bloated inflamed

the next day.

It's especially bad if you have an inflammatory disease because

the salt also increases the amount of pain in the


This is no accident.

Table salt sodium chloride activates a

special type of white blood cell called th17.

These immune cells activate a pathway called

sgk1, which results in

autoimmune disease and inflammation. That's why if you

have any type of immune or inflammatory or digestive problem.

It's important to avoid salt altogether.

Now also remember that salt is contained

in lots of foods that we don't even think about.

Most packaged Foods desserts baked

goods sauces have large

amounts of sodium.

Also, I found this really surprising chicken has

a lot of sodium because they actually injected

inside the meat sometimes the saline weight

is up to 30% of the actual meat. So pay

attention you could be inadvertently making your

situation worse by eating something that you don't

even think has any salt in it, but it does

If you're wondering what a good limit is historically many

people have said two grams, which is 2,000 milligrams.

But I think even this is too high. I think

you're better off under a gram or even 0.5 grams

or 500 milligrams, which is half a gram.

And the reason I say this is that the body has ways

of extracting salt from the normal food that we

eat. Keep in mind until a couple hundred years ago when salt

was discovered as a way of preserving meat and the

salt trade became a thing humans never added salt

to anything that they ate.

it also turns out that many of the inflammatory and immune

diseases were also more common in countries

in places where they consume large amounts of salt tnf

Alpha and il-6

In my opinion, it's one of the most important.

Whenever there's a trigger for inflammation in the body, the body

has a choice either deal with it appropriately or in

a dysfunctional way.

If the immune system decides it wants to react in

an unhelpful way. Then the body will produce inflammation that

will attack its own tissue.

Il-6 and tnf Alpha are cell signaling

molecules. You can measure in the blood that predict whether

the body will have a dysfunctional response versus a

healthy response. In fact, these cytokines are

involved in a large number of chronic diseases. One

of the most potent activators of il-6 and

tnf. Alpha is fat in the

diet specifically animal fat, especially in

red meat.

But also meets in general butter Dairy and

cheese is problematic.

The folks that have the lowest il-6 and

tnf Alpha levels follow a phytonutrient diet

which have lots of healthy vegetables and healthy

fats like olive oil.

Other things that work are intermittent fasting.

Here's another interesting study which shows that even if you don't eat perfectly

increasing the amount of phytonutrients and

specifically polyphenols in the diet will

down regulate il-6 production from food

in the intestines.

Which means even if you eat pepperoni pizza, if you drink some

phytonutrient tea afterwards, for example, it blunts

the effects of the fat sort of

like a rescue mechanism.

Also, I'm going to give you another pearl of

knowledge here. One of the simplest things you can do to drive. These

levels down are to take a vitamin D

supplement turns out if you're low on vitamin D

the aisle 6 and tnf Alpha levels shoot way up.

That's one of the theories on why equatorial countries

such as Africa where they get enough vitamin D from

the sunlight have better immune responses to illness. All

right. I hope you enjoyed that video. Now. I want to know

what types of inflammation do you experience? And what have you

tried that works leave a comment below and let me know your

thoughts. Also, if you like this video help support my channel and share this

with your fellow loved ones and be sure to subscribe for more useful tips.

You can also follow me on social at dosari MD

as always, this is Dr. Chanudasari with the mindgun immunity

clinic and I'll see you next time.

Key takeaways

 ​1) Histamine Pathway

        ​a. Histamine is produced in the gut mostly ('bad' microbes)

        b. HistaDINE is the precursor molecule

        c. Dietary sugar stimulates 'bad' microbes (Yeast, Candida, Bacteria)

   ​2)   Arachidonic Acid Pathway

        ​a. From animal-derived cholesterol

   ​2)   TNF-a, IL-6 (Tumor Necrosis Factor Alpha and Interleukin-6)

        ​a. Produces a dysfunctional immune response

        b. Vitamin D deficiency causes elevations in TNF-a/IL-6

        c. Phytonutrients help block TNF-a/IL-6

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